Vascular Relaxation by the Methanol Extract of Sorbus Cortex via NO-cGMP Pathway
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چکیده
منابع مشابه
Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats.
Placental ischemia during pregnancy is thought to release cytokines such as tumor necrosis factor-alpha (TNF-alpha), which may contribute to the increased vascular resistance associated with pregnancy-induced hypertension. We have reported that a chronic twofold elevation in plasma TNF-alpha increases blood pressure in pregnant but not in virgin rats; however, the vascular mechanisms are unclea...
متن کاملReduced endothelial NO-cGMP vascular relaxation pathway during TNF- -induced hypertension in pregnant rats
Davis, Justin R., Jena B. Giardina, Gachavis M. Green, Barbara T. Alexander, Joey P. Granger, and Raouf A. Khalil. Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-induced hypertension in pregnant rats. Am J Physiol Regulatory Integrative Comp Physiol 282: R390–R399, 2002; 10.1152/ajpregu.00270.2001.—Placental ischemia during pregnancy is thought to release cytokines such as t...
متن کاملL-arginine supplementation improves aortic vascular relaxation via NO-independent sGC/cGMP signaling in exercised rats
Background It is well established that physical training promotes beneficial effects on the vascular reactivity by improving the NO/cGMP signaling pathway [1]. L-Arginine (L-Arg) is a non-essential amino acid which plays a critical role in many organism functions such as pH regulation and endothelial cell membrane depolarization. Moreover, the benefits of the oral supplemention with L-Arg have ...
متن کاملVascular Relaxation Induced by C-Type Natriuretic Peptide Involves the Ca2+/NO-Synthase/NO Pathway
AIMS C-type natriuretic peptide (CNP) and nitric oxide (NO) are endothelium-derived factors that play important roles in the regulation of vascular tone and arterial blood pressure. We hypothesized that NO produced by the endothelial NO-synthase (NOS-3) contributes to the relaxation induced by CNP in isolated rat aorta via activation of endothelial NPR-C receptor. Therefore, the aim of this stu...
متن کاملPosttranscriptional regulation of human iNOS by the NO/cGMP pathway.
Nitric oxide (NO) and cGMP may exert positive or negative effects on inducible NO synthase (iNOS) expression. We have explored the influence of the NO/cGMP pathway on iNOS levels in human mesangial cells. Inhibition of NOS activity during an 8-h stimulation with IL-1beta plus tumor necrosis factor (TNF)-alpha reduced iNOS levels, while NO donors amplified iNOS induction threefold. However, time...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2005
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.28.860